CONTEXTUALIZING WESTERN GUIDELINES FOR STROKE AND LOW BACK PAIN TO A DEVELOPING COUNTRY (PHILIPPINES): AN INNOVATIVE APPROACH TO PUTTING EVIDENCE INTO PRACTICE EFFICIENTLY

Contextualizing Western guidelines for stroke and low back pain to a developing country (Philippines): an innovative approach to putting evidence into practice efficiently

Consuelo Gonzalez-Suarez,1,2,3 Karen Grimmer-Somers,1 Janine Margarita Dizon,1 Ellena King,1 Sylvan Lorenzo,2 Carolina Valdecanas,2 Ephraim Gambito,2 Belinda Fidel2,31International Center for Allied Health Evidence, University of South Australia, Adelaide, Australia; 2Philippine Academy of Rehabilitation Medicine, Quezon City, Philippines; 3Univers

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Geographic distribution of conversion therapy prevalence in Canada. Findings from a national cross-sectional survey, 2020 [version 2; peer review: 1 approved, 2 approved with reservations]

Background: Conversion therapy practices (CTPs) are discredited efforts that target lesbian, gay, bisexual, trans, queer, Two-Spirit, or other (LGBTQ2S+) people and seek to change, deny, or discourage their sexual orientation, gender identity, and/or gender expression.This study aims to investigate the prevalence of CTPs across Canadian provinces a

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Transcranial lateral perforating gunshot injury through skull base presenting without residual damage: A fortunate survivor

We reported a case of a 32 years old male presenting with a perforating gunshot injury in craniocerebral region 3 h after the assault.The bullet entered above the right zygomatic arch, travelling through the coronal plane, and Stove Clock Knob exited from the left zygomatic arch.The patient was fully conscious at presentation and developed facial n

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Substrate and mechanotransduction influence SERCA2a localization in human pluripotent stem cell-derived cardiomyocytes affecting functional performance

Physical cues are major determinants of cellular phenotype and evoke physiological and pathological responses on cell structure and function.Cellular models aim to recapitulate basic functional features of their in vivo counterparts or tissues in order to be of use in in vitro disease modeling or drug screening and testing.Understanding how culture

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Cellular Senescence: A Translational Perspective

Cellular senescence entails essentially irreversible replicative arrest, apoptosis resistance, and frequently acquisition of a pro-inflammatory, tissue-destructive senescence-associated secretory phenotype (SASP).Senescent cells accumulate in various tissues with aging and at sites of pathogenesis in many chronic diseases and conditions.The SASP ca

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